Clinical abstract from Cukurova University: Glutathione as an oral whitening agent: A randomized, double-blind, placebo-controlled study
“… Sixty otherwise healthy medical students were randomized to receive either glutathione capsules, 500 mg/day in two divided doses, or placebo for 4 weeks. The main outcome was mean reduction of melanin indices measured at six different sites. Several secondary outcomes, including UV spots, were recorded by VISIA™. Efficacies of glutathione and placebo were compared by ANCOVA with baseline values as co-variates. At 4 weeks, the melanin indices decreased consistently at all six sites in subjects who received glutathione. This was similarly reflected in the changes in the number of UV spots, as measured by VISIA..…”
Conclusion: Oral glutathione administration results in a lightening of skin color in subjects.